Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :EBE-A22229476-53-3HY-14347374.23C17H16BrN3O2>98%Solubility:DMSOMechanisms: Pathways:Others; Target:Others Biological Activity:ppy,EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22is inactive. IC50 value: Target: The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivityfor the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkablecytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designatedEBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. The present study wasperformed to explore the possibility that PD153035 and its N-methyl analogue might interact withdouble-stranded DNA, which is a primary target for many conventional antitumor agents. We studiedthe strength and mode of binding to DNA of PD153035 and EBE-A22 by means of absorption,fluorescence, and circular and linear dichroism as well as by a relaxation...References:[1]. Goossens JF, et al. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr 17;40(15):4663-71. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr
