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专利名称：Methods of identifying longevity
modulators and therapeutic methods of usethereof
发明人：Heidi A. Tissenbaum,Seung Wook Oh申请号：US10746910申请日：20031223
公开号：US20050037440A1公开日：20050217
摘要：The present invention is based at least in part on the discovery of a role for theJNK signaling pathway in longevity. In particular, the present inventors have shown thatmodulation of the c-jun N-terminal kinase (JNK) signaling pathway in an organism,optionally in combination with modulation of the insulin receptor (IR) signaling pathway,can enhance longevity in an organism. Accordingly, the present invention featuresmethods of identifying modulators of longevity in assays featuring organisms and/orcells having either a functional or deregulated JNK signaling pathway and, optionally, afunctional or deregulated IR signaling pathway. Also featured is an in vitro method ofidentifying an agent capable of enhancing longevity featuring an assay compositionhaving a JNK signaling pathway molecule and insulin signaling pathway molecule. Furtherfeatured are therapeutic methods for the use of JNK signaling pathway modulators toenhance longevity.
申请人：Heidi A. Tissenbaum,Seung Wook Oh
地址：Wayland MA US,Westborough MA US
国籍：US,US
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